with great pain

A 45-degree angle was optimal because it would have aided movement, yet would not have been so great so as to expose women to the back pain and risk of slipped discs that can come with excessive spinal curvature.

45度是最理想的，因为这有助于人们行动，但是也有不好的地方，因为如果脊椎过度弯曲，将会导致背痛或者有椎间盘突出的风险。

The soldier bore the sharp pain in the wound with great courage.

这士兵以巨大的勇气忍受着伤口的剧烈疼痛.

Associated with or relating to great pain, especially the agony of death.

痛苦的关于或与巨大痛苦有关的，尤指死亡的痛苦。

Hypercalcaemia and bone metastases of malignancy are frequently diseases in advanced cancer patients, it threatens patients' life and brings the patients with great pain.

高钙血症和恶性肿瘤骨转移是晚期肿瘤患者的常见疾病，危及患者的生命并给患者带来巨大的痛苦。